Al-Libi, known as a rock star in the jihadist world with his videos and lectures going viral on the Web, was the intended target of the strike, U.S. officials said.
The strikes have been increasingly unpopular among Pakistanis, but successful in recent years at taking out terrorist leaders.
Pakistan has evidence that Al-Libi was in a house hit by the U.S. drone strike, but it was initially unclear whether he was killed.
A U.S. official later confirmed his death.
“Abu Yahya was among al-Qaeda’s most experienced and versatile leaders,” the official said. He “played a critical role in the group’s planning against the West, providing oversight of the external operations efforts.”